Polycystic Ovary Syndrome in a Sample of Type 1 Iraqi Diabetic Women
Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in premenopausal women, recently an increased prevalence of polycystic ovary syndrome has been observed in adult women with type 1 diabetes mellitus (type 1 DM).
Objective: To determine the incidence or frequency of polycystic ovary syndrome and hyper androgenic disorders in Iraqi women with Type 1 diabetes mellitus and evaluate whether these abnormalities are related to the supra physiological doses of insulin.
Methods: The study was conducted at Department of Physiology, Medical College of AlMustansyriah University in cooperation with the Iraqi National Centre for Diabetes of AlMustansyriah University in Baghdad from July 2009 till July 2010. Forty one Iraqi women with type 1 diabetes mellitus (aged 19-40 years) were included in this study. Hormonal assay (Follicular stimulating hormone, luteinizing hormone, progesterone and testosterone) were done for all of them. Glycemic control was assessed by HbA1c. Study of ovarian morphology and ovarian volume was determined by trans-abdominal ultrasonography. We compared the clinical, hormonal and glycemic control of 19 women with polycystic ovary syndrome and type 1 diabetes mellitus and 22 women with type 1 diabetes mellitus without polycystic ovary syndrome
Results: The present study showed that 19 women with type 1 diabetes mellitus out of 41 have polycystic ovary syndrome. Women with type 1 diabetes mellitus that have diabetes before menarche were more susceptible to have polycystic ovary syndrome later on their life. Also women are being treated with supra physiological doses of insulin are more liable to have polycystic ovary syndrome. Luteinizing hormone and testosterone showed significant difference between women with type 1 diabetes mellitus and polycystic ovary syndrome and women with type 1 diabetes mellitus without polycystic ovary syndrome.
Conclusions: A high frequency of hyperandrogenism, polycystic ovary syndrome and polycystic ovarian morphology (PCOM) is observed in type 1 diabetes mellitus, which appears to be associated with intensive insulin treatment. So physicians treating women with type 1 diabetes mellitus should be aware of the risk of hyperandrogenism among them.
Keywords: Polycystic ovary syndrome, Polycystic ovarian morphology, Type 1 diabetes mellitus.
Copyright (c) 2011 Iraqi Medical Journal
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