Distribution of HLA Antigens Class I and II in Baghdad Arab Population
Abstract
ABSTRACT
Background: The highly polymorphic human leukocyte antigen (HLA) system has been validated as useful for distinguishing and/or relating populations (and individuals) in many research studies
Objectives: To study the HLA phenotype frequencies in Baghdad and surrounding cities.
Methods: This retrospective study was conducted in Bone Marrow Transplant Center in Baghdad from December 2010 to January 2011. Apparently healthy unrelated bone marrow donors from 100 families were typed for HLA class I and class II using sequence specific primers for polymerase chain reaction (PCR-SSP). Only one member of each family was included in the study; all these families are resident in Baghdad and surrounding citie
Results: The study showed that the highest frequent HLA-A antigens were A2 (18%), A3 (15.5%), A24 (13.5%) and A1 (12.5%) while the lowest frequent A antigens were A34 (0.5%), A66 (0.5%) and A80 (0.5%). Regarding HLA-B antigens, the highest frequent antigens were B35 (20%), B51 (12%), B50 (8%), B44 (6.5%) and B7 (6.5%) while the lowest frequent B antigens were B53 (0.5%), B54 (0.5%), B64 (0.5%) and B81 (0.5%). Regarding HLA-C antigens, the highest frequent antigens were C12 (20.6%), C4 (15.7%), C7 (14.6%), and C6 (13%) while the lowest frequent C antigens were C18 (0.5%), and C14 (1%). The study showed that the highest frequent DRB1 antigens were DR11 (21%), DR7 (14.5%), DR4 (13%) and DR3 (13%) while the lowest frequency of DRB1 antigens was DR9 (0.5%).
Conclusions: The highest frequent antigens were A2, B35, C12 and DR11. The results of this study showed similarity to other studies in Iraq and surrounding Arab countries.
Copyright (c) 2012 Iraqi Medical Journal
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