Serum Ferritin in Obese and Overweight Women with Polycystic Ovary Syndrome
Abstract
ABSTRACT
Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulation, hyperandrogenism, insulin resistance and obesity. Body iron stores are positively associated with glucose intolerance, type 2 diabetes mellitus, and metabolic syndrome. It is reported that serum ferritin levels increase in women with polycystic ovary syndrome.
Objective: In this study body iron stores (i.e. serum ferritin) were evaluated in women with polycystic ovary syndrome, especially those over weight and obese.
Methods: A case-control study over a period of one year from the first of April 2010 till the end of April 2011. The study consisted of 2 groups: the first group consisted of forty-five women (group A) with polycystic ovary syndrome. And the second group consisted of forty-five women (group B) without evidence of polycystic ovary syndrome taken as control; both groups were subdivided according to the body mass index into lean, overweight and obese. Serum ferritin levels were measured in both groups and the results correlated with body mass index, menstrual abnormality and oral glucose tolerance test.
Results: Mean serum ferritin levels in patients with polycystic ovary syndrome were increased significantly in overweight and obese women (61.27±5.97) than the lean (21.98±5.47) and control (29.80±6.13) group, (P value ≤ 0.0001).
Conclusions: Serum ferritin level is significantly raised in over weight and obese women with PCOS but not in lean women in comparison to the control group
Copyright (c) 2012 Iraqi Medical Journal
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