Changes of Serum Ascorbic Acid and Serum Uric Acid in Gestational Diabetes Mellitus
Abstract
ABSTRACT
Background: There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Over production and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids
Objective: To assess ascorbic acid and uric acid levels in gestational diabetes mellitus.
Methods: This is a case-control study which was carried out in the Obstetrics and Gynecology department of Al-Kadhimiya Teaching Hospital between April 2010 and April 2011. The study was conducted on 120 pregnant women with a single viable fetus, at 2839 weeks of gestation attending the antenatal clinic. It included sixty pregnant women diagnosed as having gestational diabetes mellitus, and a control group of sixty healthy normotensive pregnant women. Blood samples were withdrawn after overnight fasting and vitamin C was estimated using high performance liquid chromatography method. Serum uric acid was estimated by using colorimetric method.
Results: There was a significant decrease in the serum ascorbic acid (2.09) with p-value < 0.001 and a significant increase in the serum uric acid (333.08) with p-value < 0.001 in gestational diabetic group compared to control group. Ascorbic acid and uric acid levels showed a significant negative correlation
Conclusion: Serum ascorbic acid level significantly decreased and serum uric acid significantly increased in pregnant women with gestational diabetes mellitus.
Copyright (c) 2012 Iraqi Medical Journal
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