Altered Lipid Profile in Patients with Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome is the most common endocrine disorder in reproductive age. Recent studies have shown that polycystic ovary syndrome is not only a gynecological condition affecting women of reproductive age but also a comprehensive syndrome with a variety of associated metabolic disorders, such as insulin resistance and dyslipidaemia. Dyslipidaemia is the most common metabolic abnormality in polycystic ovary syndrome, although the type and extent of findings have not been defined. 

Objective: To investigate the lipid profile in patients with polycystic ovary syndrome.

Methods: Between October 2012 and October 2013, forty polycystic ovary syndrome patients and forty healthy controls matched for body mass index and age were recruited into the study, where the serum lipid profile were determined for polycystic ovary syndrome patients and compared to healthy control: lipid profile consist of total cholesterol, triglyceride, and high density lipoprotein cholesterol which measured by spectrophotometer by enzymatic colorimetric method.

Results: This study has showed no significant difference in the body mass index (31.004±2.4232 vs. 31.2±2.7988; p=0.2497), total cholesterol (168.4324±36.84 vs. 176.454±27.724; p=0.142) and low density lipoprotein level (99.8±32.75 vs. 91.1364±14.0112; p=0.062) between polycystic ovary syndrome and healthy control. Triglycerides level was significantly higher in polycystic ovary syndrome than healthy control (168.6±34.6401 vs.129.625±45.4125. p=0.001). High density lipoprotein level were significantly lower in polycystic ovary syndrome group (40.3143±7.5994vs. 45.7272±11.348 p=0.001).

Conclusion: Women with polycystic ovary syndrome affected by dyslipidaemia and had unfavorable lipid profile characterized by high triglycerides and low high density lipoprotein level.