The Correlation between Maternal and Neonatal Thyroid Hormone Concentration with Fetal Malpresentation at Term Pregnancy
Abstract
ABSTRACT
Background: Abnormal fetal presentation are generally associated with maternal and neonatal morbidity and mortality. Recently abnormal thyroid hormone concentration were claimed to cause abnormal presentation of fetus at term.
Objective: To evalute the role of thyroid hormone changes in association with fetal malpresentation at term pregnancy.
Methods: A case control study was done at Department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital for a period of one year from January 2012 to January 2013. Hunderd pregnant women with singleton fetuses were divided into two groups: first group included 50 pregnant women with malpresented fetus at term pregnancy were taken as study group and second group included 50 pregnant women with vertex presented fetus were taken as control group. For both groups blood samples collected from the mothers for thyroid stimulating hormone and free thyroxin hormone (TSH, fT4) and their neonates for thyroid stimulating hormone and throxine hormone (TSH, T4) measurment and the results were compared between the two groups.
Results: A significant relationship was found between higher level of maternal TSH and malpresentation in comparison with vertex group since the p value 0.0001, also significant relationshipe was seen between fetal malpresentation with level of cord blood T4 lower than that for vertex group with P value 0.001.
Conclusion: Women with higher level of TSH at the end of pregnancy and lower level of cord blood thyroxin in the neonate of term pregnancy are at risk for malpresentation, and thus for obstetrical complications.
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