Role of Initial Monocyte Count on the Outcome of Patients with Neonatal Sepsis
Abstract
ABSTRACTBackground: Neonatal sepsis is a clinical syndrome characterized by many signs and symptoms which are non specific for diagnosis. Blood culture is standard measure but needs time to give its results. Monocyte count is now used for early detection and follow up of patients of neonatal sepsis.
Objectives : To evaluate the role of initial monocyte count in the follow up of patients with neonatal sepsis.
Methods: The number of studied cases were 46 neonates diagnosed as a cases of neonatal sepsis after positive blood culture. A similar number were taken as a control group. Each one was assessed clinically by prepared questionnaire including history and clinical assessment. Laboratory parameters includes monocyte count was done for all included cases. Eight babies were died during the first week of the therapy and 38 cases were followed up after 1week.by the same parameter that mentioned above.
Results: Very early neonatal sepsis was the commonest clinical type of sepsis 30 (65,2%) with poor feeding is the common presentation 40 (87%). Group B streptococcus (GBS) was the commonest bacteria isolated in 17 cases (37%). Before therapy, monocyte count was high in 31 (67,4%). After 1 week of therapy, the monocyte count was high in 6 cases (15.8 %) only. The higher percent of high monocyte count 7(87.5%) found in patients who died during first week of therapy and 24 (63.1%) in patients who discharged well, while the normal count was found in 1 (12.5%), and 14 (36.9%), respectively.
Conclusion: It is concluded that the monocyte count is a good predictor test than for diagnosis and follow up of patients with neonatal sepsis.
Keywords: Sepsis, Monocyte, Prematurity, Low birth weight.
Iraqi Medical Journal Vol. 56, No.1, June 2010; p.32-38
Copyright (c) 2017 Iraqi Medical Journal
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