Esophagogastroduodenoscopic Finding in Celiac Disease Endoscopic Research
Abstract
ABSTRACTBackground: Some patients with diarrhea-predominant irritable bowel syndrome and non-ulcer dyspepsia may have undiagnosed celiac disease. Because the symptoms of celiac disease respond to gluten-free diets, testing for celiac disease in those patients may prevent years of morbidity and attendant expense.
Objectives: Testing for celiac disease in patients with diarrhea- predominant irritable bowel syndrome and non-ulcer dyspepsia.
Methods: Forty patients with irritable bowel syndrome and non-ulcer dyspepsia were studied to determine the frequency of celiac disease incidence. All patients underwent esophagogastro-duodenoscopy with distal duodenal biopsies were taken to determine any mucosal abnormalities and serum was obtained to measure antigliadin antibodies.
Results: Four of 40 (10%) of the studied patients proved to have positive serological evidence and histopathological evidence of celiac disease. Of the above positive patients, 3(75%) had irritable bowel syndrome and 1 (25%) had symptoms of non-ulcer dyspepsia. So celiac disease is more prevalent in irritable bowel syndrome patients.
Conclusions: Celiac disease is a common finding among Iraqi patients labeled as irritable bowel syndrome and non-ulcer dyspepsia. In this subgroup, a gluten-free diets may lead to a significant improvement in symptoms and avoid the subsequent complications.
Keywords: Esophagogastro-duodenoscopy, Celiac disease, Irritable bowel syndrome.
Iraqi Medical Journal Vol. 56, No.1, June 2010; p.39-43
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