The Effectiveness of The Effectiveness of Lisuride in the Treatment of Hyperprolactinemia
Abstract
ABSTRACTBackground: Hyperprolactinemia is a common endocrine abnormality. It may be presented with one or more of the following: amenorrhea, galactorrhea and infertility. Lisuride is one of dopamine agonist.
Objective: To assess the effectiveness of lisuride in the treatment of hyperprolactinemia and its related problems.
Methods: An interventional study which extended from October 2008 till October 2009. Fifty patients were complained from either one or more of the following oligomenorrhea, amenorrhea, galactorrhea and infertility. Patients with polycystic ovary syndrome, thyroid disorder, patients on medication known to increase prolactin level and those with galactorrhea and normal serum prolactin level were excluded from the study.
All patients received lisuride 0.1 mg (half tablet of 0.2 mg) on 1st day, 0.1 mg twice on 2nd day and 0.1 mg three times on 3rd day and continued for 12 weeks. Every patient was seen at monthly interval were history of menstrual cycle, presence of breast secretion and side effects of the drug were recorded. Serum prolactin level was measured. Ovulation was detected by serum progesterone at day 21 and ultrasound scan. Lisuride was discontinued once pregnancy was confirmed.
Results: Fifty patients, their mean age  was 27.5 years ± SD 8.1 years, their mean weight was 63.1 kg ± SD 5.1. All patients had raised serum prolactin level, the mean was 66.7 ng/ml ± SD 20.3. Thirty two patients were complaining of oligomenorrhea, twelve patients with amenorrhea, six patients with regular cycle, twenty four patients with unovulatory infertility and five patients with galactorrhea, after 12 week treatment with lisuride, a significantly lower serum prolactin was obtained with mean 12.96 ng/ml ± SD 4.7 (P=0.0001), and a significantly lower number of patients had raised serum prolactin at end of treatment ( P=0.000001). Regular  menstrual cycle  was returned in significant number of patients at the end of treatment (P=0.0001). Ovulation was detected in a significant number of patients at the end of treatment ( P=0.000001). Galactorrhea was stopped in 80% of patient at the end of 12 weeks, but  the result not reach the level of statistical significant, most of the patients developed side effects to the drug during treatment but were tolerable.
Conclusion: Lisuride is an effective drug in the treatment of hyperprolactinemia and it related problems in the presence of good patients compliance.
Keywords: Lisuride, Hyperprolactinemia, infertility.
Iraqi Medical Journal Vol. 56, No.1, June 2010; p.50-54
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